Wetlands exist in a transitional zone between aquatic and terrestrial environments, and thus can be altered by slight changes in hydrology. Climate Change predictions for the tropics gives mixed results with some areas in East Africa expected to receive below normal rainfall. The semi-arid areas of the Lake Victoria Basin, the floodplains, would be warmer with frequent and prolonged drought events. These changes, however subtle, are likely to affect the functioning of many freshwater wetlands. Potential impacts will range from changes in community structure to changes in ecological function, and from extirpation to enhancement. This will have implications on the well-being of riparian communities who rely on wetlands for the supply of essential goods and services. The important role of wetlands in the global carbon cycle will also be affected; tropical wetlands are able to sequester 80% more carbon than temperate wetlands. Currently, the effects of Climate Change are being felt by residents in the riparian areas. However, the changes have not been investigated to determine the extent to which they might affect the supply of goods and services to people living in the adjacent areas. Mitigation strategies for minimizing the adverse impacts of Climate Change on the wetland ecosystem include reduction of current anthropogenic stresses, active management to preserve wetland hydrology, and a wide range of other management and restoration options. For the dependent communities, existing anomalous mitigation measures need to be enhanced, and planned mitigation mechanisms put in place. Adaptation and coping strategies which are being employed by the people also need to be strengthened. However, appropriate measures cannot be put in place without tangible evidence of the extent and trend of climate related impacts on wetland ecosystem function which affect the flow of goods and services. This chapter gives the perspective of the riparian communities of the Nyando Wetland on the impacts of climatic changes and possible mitigating measures which should be carried out to ensure sustainable management of the wetland resources.